It's about a six hour drive from Arequipa.
The first half of the journey is on a great scenic road (that goes to Colpa canyon), and passes by Chachani and great landscapes - expect to see a lot of Vicunas.
Before the road reaches Colpa canyon, you turn left on a dirt track from where you might as well have gone back in time hundreds of years. It's a very scenic route then towards the valley where you'll find the base camp. A 4x4 is absolutely necessary - the route gets fairly water logged and you'll cross a couple of small streams.
Finally you'll be able to drive straight up to base camp at 5,200 meters.

Ampato is a stratovolcano located in the Andes of southern Peru, near Arequipa. It's known primarily for its historical significance as the site where the Inca Ice Maiden, Juanita, was discovered, preserved in ice near the summit. Climbing Ampato offers a moderately challenging ascent, usually tackled from a base camp around 4,900 meters, with the main challenge being the final push to its summit at 6,288 meters. The route involves glacier travel, so crampons and ice axes are essential. Weather conditions can vary greatly, and the wind can pick up unexpectedly, making the final stretch quite demanding. After climbing you can check out the Mummy museam in Arequipa and see the previous climber...

End of the trail, 4x4 needed to reach. Otherwise you can camp at 4,800.

Base Camp

A place to make camp, flat and somewhat sheltered. No water.

High Camp

The summit of Ampato offers breathtaking views of the surrounding volcanoes and landscapes, including the nearby Sabancaya volcano. The summit push from high camp involves navigating glaciers and potential snowfields.

Summit

You can drive as high as 5,200m, but some stop earlier and make base camp between 4,800-5,000. 
There are spaces for a high camp at 5,500 too, but this is less necessary if you start at the absolute end of the road (5,200).

From base camp you slowly move up decent but loose terrain to high-camp (optional). From there it's a few hundred more vertical meters to the glacier. You can either go up the glacier or to its left (when looking up the mountain), but the ground is pretty loose so most go up the glacier and down the scree. From where the glacier tops out you're still 200 meters from the summit. A route up to the left is typical, as straight ahead to the summit has a lot of loose scree. Otherwise you can go right to a false summit and follow the ridge to the summit - but that's a longer way.

Shortly before base camp, after you cross the last stream there is an abandoned house/farm of sorts. It used to be a place to stay, but now is a relic of the past.
Either you drive in (with a 4x4) with absolutely everything you'll need, or go on an organised expedition from Arequipa.
The base camp is a three hour off-road drive on a route that sees very little traffic.

Ampato

Yayamari, also known as Apu Yayamari, stands at around 6,049 meters (19,845 feet) in the remote Peruvian Andes, within the Vilcanota Mountain Range. This peak, often overlooked by climbers in favor of nearby Ausangate, offers a strikingly beautiful but challenging ascent for experienced mountaineers looking to explore Peru&rsquo;s high-altitude wilderness.
The mountain holds spiritual significance for the local Quechua communities, who revere Yayamari as an Apu (sacred mountain spirit). Climbers here are treated not only to incredible views of surrounding glaciated peaks and turquoise lakes but also a deep cultural experience, as the mountain&rsquo;s sacred status contributes to its unique atmosphere.
Yayamari&rsquo;s ascent involves mixed terrain, including snowfields, glaciers, and rocky ridges. The approach requires solid navigation skills, as trails are less defined, and climbers must be prepared for remote conditions. Summit routes demand technical knowledge of snow and ice climbing, along with acclimatization due to Yayamari&rsquo;s height. The weather in this part of the Andes can change rapidly, adding to the mountain&rsquo;s challenges.
Reaching the summit provides spectacular panoramic views, a rewarding experience for those seeking both a challenging ascent and a meaningful connection to Peru&rsquo;s cultural heritage and breathtaking landscapes.

Yayamari

Khan Tengri's marble-like pyramid shape offers a visually stunning climb, set against the backdrop of the Central Tien Shan range. Known for its challenging mixed terrain and the ethereal glow it casts during sunset, this peak provides an unforgettable mountaineering experience.

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